Biology of platelet-derived growth factor

Publisher: Karger in Basel, New York

Written in English
Cover of: Biology of platelet-derived growth factor |
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  • Platelet-derived growth factor.,
  • Platelet-Derived Growth Factor.

Edition Notes

Includes bibliographical references and index.

Statementvolume editors, B. Westermark, C. Sorg.
SeriesCytokines ;, v. 5
ContributionsWestermark, Bengt., Sorg, Clemens.
LC ClassificationsQP552.P56 B56 1993
The Physical Object
Paginationviii, 167 p. :
Number of Pages167
ID Numbers
Open LibraryOL1742341M
ISBN 103805556357
LC Control Number92049345

Lung cancer is the most common cause of death by cancer in developed countries. Since a tumor cannot develop without the parallel expansion of a tumor stroma, a better understanding of its formation could lead to new therapeutical approaches. In this respect, since platelet-derived growth-factor (PDGF) is a chemotactic and growth factor for mesenchymal and endothelial . Blockade of platelet-derived growth factor signalling with neutralizing antibody or with small molecule inhibitors of platelet-derived growth factor receptor kinase or downstream phosphatidylinositol 3 kinase eliminated retinal ganglion cell neuroprotection conferred by mesenchymal stem cell co-culture. Platelet-derived growth factor (PDGF) Sources. Platelets, macrophages, endothelial cells, smooth muscle cells, keratinocytes. Platelet-derived growth factor (PDGF) Functions. They also release wound healing-associated growth factors including platelet-derived growth factor (PDGF), which directs cell movement; TGF beta, which stimulates the deposition of extracellular matrix tissue into a wound during healing; and vascular endothelial growth factor (VEGF), which stimulates angiogenesis, or the regrowth of blood vessels.

Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation. 1 PDGF elicits multifunctional actions with a variety of cells, including mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts. Ovarian Cancer Immunotherapy provides a broad overview of several aspects of basic sciences and clinical and therapeutic aspects of immunotherapy for ovarian cancer, as well as state-of-the-art information on molecular genetics and biology. Chapters are written by a team of expert contributors from around the world and explore topics such as antibody therapeutics for .   Neurons synthesise and secrete many growth and survival factors but it is not usually clear whether they are released locally at the cell body or further afield from axons or axon terminals. Without this information, we cannot predict the site(s) of action or the biological functions of many neuron-derived factors. For example, can neuronal platelet-derived growth factor . Adipocytes arise from distinct progenitor populations during developmental and adult stages but little is known about how developmental progenitors differ from adult progenitors. Here, we investigate the role of platelet-derived growth factor receptor alpha (PDGFRα) in the divergent regulation of the two different adipose progenitor cells (APCs).

  Platelet-derived growth factor receptor-beta (PDGFRβ) is a receptor tyrosine kinase found in cells of mesenchymal origin such as fibroblasts and pericytes. Activation of this receptor is dependent on paracrine ligand induction, and its preferred ligand PDGFB is released by neighboring epithelial and endothelial cells. While expression of both PDGFRβ and PDGFB . receptors, platelet-derived growth factor specific molecular sites or structures on cell membranes that react with platelet-derived growth factor, its analogs, or antagonists, to elicit or to inhibit the specific response of the cell to this factor. Type 2 diabetes mellitus is a type of metabolic disorder characterized by hyperglycaemia with multiple serious complications, such as diabetic neuropathies, diabetic . As one of numerous growth factors, platelet-derived growth factor (PDGF) was originally identified as platelets and serum mitogen for fibroblasts, smooth muscle cells (SMC), and glial cells. 13 PDGFs can also be secreted by endothelial cells, SMC, and fibroblast. 14 The protein PDGFA and PDGFB can dimerize to form PDGF-AA, PDGF-BB, and PDGF-AB.

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Biology of. Platelet Derived Growth Factor (PDGF): Platelet Derived Growth Factor is the evolutionary sentinel growth factor that initiates nearly all wound healing.

It exists in three dimeric forms: PDGFaa, PDGFbb, and PDGFab. Each form is active but the specific role of each one has not been determined as yet. This volume collects material on the structure, function and signal transduction pathway of platelet-derived growth factor (PDGF), a cytokine which is likely to be an important signal substance in Read more.

M.A. Anzano, A.B. Roberts, Biology of platelet-derived growth factor book. SpornAnchorage-independent growth of primary rat embryo cells is induced by platelet-derived growth factor and inhibited by type β transforming growth factor J.

Cell. Physiol., (), pp. Cited by: Anthony P. Adamis MD, in Retinal Pharmacotherapy, PLATELET-DERIVED GROWTH FACTOR. The PDGF family consists of four related dimeric polypeptides (PDGF-A through PDGF-D) 61 that are structurally related to VEGF. 2 In general they occur as homodimers, although the PDGF-AB heterodimer has also been identified.

61 PDGFs are ligands for two. Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and particular, PDGF plays a significant role in blood vessel Biology of platelet-derived growth factor book, the growth of blood vessels from already-existing blood vessel tissue, mitogenesis, i.e.

proliferation, of mesenchymal cells such as fibroblasts, osteoblasts, tenocytes, vascular smooth muscle. platelet-derived growth factor n a mitogenic growth factor that is found esp. in platelets, consists of two polypeptide chains linked by bonds containing two sulfur atoms each, stimulates cell proliferation (as in connective tissue, smooth muscle, and glia), and plays a role in wound healing abbr.

PDGF. Growth factors have been used successfully in humans to treat previously incurable wounds. The most intensively studied growth factors are epidermal growth factor (EGF), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), transforming growth factor (TGF)-α, and TGF-β.

Platelet-derived growth factor (PDGF) was identified more than three decades ago as a serum growth factor for fibroblasts, smooth muscle cells (SMCs), and glia cells (Kohler and Lipton ; Ross et al. ; Westermark and Wasteson ).Human PDGF was originally identified as a disulfide-linked dimer of two different polypeptide chains, A and B, separable.

A growth-promoting “activity” released from activated platelets, the platelet-derived growth factor (PDGF), was discovered and characterized while investigating the cellular and molecular mechanisms underlying the formation of the lesions of atherosclerosis.

Because the chemokine/growth factor platelet-derived growth factor (PDGF) has been shown in previous reports to be up-regulated in the areas around the blood vessels in the brains of macaques with simian immunodeficiency virus infection, 4 we hypothesized that cocaine-mediated disruption of the endothelial barrier could involve PDGF.

•: Growth factors (bone morphogenetic protein, transforming growth factor-beta, fibroblast growth factor, platelet-derived growth factor, and insulin-like growth factor) are proteins secreted by cells that act on the appropriate target cell or cells to carry out a specific action.

Anchorage-independent growth of primary rat embryo cells is induced by platelet-derived growth factor and inhibited by type β transforming growth factor. Cell.

Physiol. ; PubMedCited by: Platelet-Derived Growth Factor. Platelet-derived growth factor is a dimer of M r 30, PDGF is the product of two genes, PDGF A and B, which give rise to two distinct PDGF chains with 60% homology (97). PDGF exists as a homodimer or heterodimer of these two chains, which can combine to form PDGF AA, BB, and AB.

Peter M. Black, Farazana Tariq, in Meningiomas, Platelet-Derived Growth Factor. There are four different isoforms of PDGF: PDGF-A, PDGF-B, PDGF-C, and PDGF-D; the situation is made more complex by the fact that in human tumors these molecules dimerize as PDGF AA, PDGF BB, and PDGF AB to create active forms.

6–8 These activate a cellular response. Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta.

Studies using Northern blot analysis, polymerase chain reaction (PCR), and immunohistochemistry have all demonstrated that meningiomas express transcripts for three members of the platelet-derived growth factor family: PDGF-A, PDGF-B, and PDGFR-B.

6–8 Although both PDGF-A and PDGF-B are present in meningiomas, PDGF-BB is the major. Platelet-derived growth factor (Science: growth factor) The major mitogen in serum for growth in culture of cells of connective tissue origin. It consists of 2 different but homologous polypeptides A and B (~30, D) linked by disulphide bonds.

Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration and proliferation.

Using bone marrow–derived human adult mesenchymal stem cells (MSCs) that did not express VEGF receptors, we provide evidence that VEGF-A can stimulate platelet-derived growth factor receptors (PDGFRs), thereby regulating MSC migration and proliferation.

Evolutionary Divergence of Platelet-Derived Growth Factor Alpha Receptor Signaling Mechanisms T. Guy Hamilton, Richard A. Klinghoffer, † Philip D. Corrin, and Philippe Soriano * Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation.

Usually it is a secreted protein or a steroid factors are important for regulating a variety of cellular processes. Growth factors typically act as signaling molecules between cells. Examples are cytokines and. Platelet-derived growth factor (PDGF) is mainly believed to be an important mitogen for connective tissue, especially for fibroblasts that serve in wound healing.

However, PDGF also has important roles during embryonal development, and its overexpression has been linked to different types of fibroti. Uncontrolled cell division produces cancerous tissue. The rate of cell division is controlled by molecules known as growth factors as well as by environmental cues.

One example of a growth factor is platelet-derived growth factor (PDGF). This growth factor is produced by platelets (a type of blood cell) in the vicinity of a wound. A number of growth factors/cytokines have been reported to affect, directly or indirectly, HDF motility.

They include basic and acidic fibroblast growth factors, transforming growth factor-β 1 and β 2, and vascular endothelial growth factor and platelet-derived growth factor (PDGF) (reviewed by Singer and Clark, ; Imanishi et al., ). Platelets release platelet-derived growth factor (PDGF), a potent chemotactic agent; and TGF beta, which stimulates the deposition of extracellular matrix; fibroblast growth factor, insulin-like growth factor 1, platelet-derived epidermal growth factor, and vascular endothelial growth factor.

The systems used for preparing autologous platelet-derived growth factors are FDA approved under the (k) process. In general, the systems are approved to be used at the patient’s point of care and/or in a clinical laboratory to prepare autologous platelet-rich plasma/platelet concentrate from the patient’s own blood.

The molecular biology of platelet-derived growth factor. Division of Cell Growth and Regulation Dana-Farber Cancer Institute and Department of Microbiology and Molecular Genetics Harvard Medical School Boston, Massachusetts USA. Search for articles by this author.

Bone growth factors affect the process of bone remodeling. These factors include insulin-like growth factors I and II, transforming growth factor beta, fibroblast growth factor, platelet-derived growth factor, and bone morphogenetic proteins. Bone volume is determined by the rates of bone formation and bone resorption.

Guangli Suo, Yong Jiang, Bryan Cowan, Jean Y.J. Wang, Platelet-Derived Growth Factor C Is Upregulated in Human Uterine Fibroids and Regulates Uterine Smooth Muscle Cell Growth1, Biology of Reproduction, /biolreprod, 81, 4. x Hematopoietic cell transplantation (HCT) is an established therapy to control and/or cure many malignant and nonmalignant hematologic diseases, congenital and acquired diseases of the immune system, some solid tumors, and some inherited disorders of metabolism [1].

The Center for International Blood and Marrow Transplant Research (CIBMTR) database receives data. Platelet Derived Growth Factor Activates fibroblasts to synthesize collagen Stimulates vascular remodeling. What secretes PDGF?

Platelets and activated macrophages at the wound site. What does PDGF act on? PDGFR homodimers, which have a tyrosine kinase domain.Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family.

PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer.

There are two forms of the PDGF-R, alpha and beta ."Prepared for the National Cancer Institute by the Cancer Information Dissemination and Analysis Center (CIDAC) for Carcinogenesis and Cancer Biology"--Page 2 of cover.

"September "--Cover. Description: 85, 12, 4 pages. Series Title: Oncology overview. Other Titles: Selected abstracts on platelet-derived growth factor (PDGF) Responsibility.